Immunohistochemical phenotype of fallopian tubes in patients with different grades of serous ovarian carcinoma

During recent years, there is an accumulating evidence that high grade ovarian carcinoma developed from the fallopian tube epithelial lesions. However, not yet completely understood and still represents subject of investigation. We investigated immunohistochemical phenotype matched tubes patients with different types malignancy grades carcinoma. Matched cancer were available in 260 cases, including mucinous borderline tumor (n=25), (n=15), serous (n=90), low (n=72) (n=48). Immunohistochemical investigation included markers proliferation (Ki67), apoptosis (Bcl2, p53), hormone receptors (ER, PR), differentiation (CK7), mesenchymal (vimentin, calretinin) stem cells (CD44). The results indicate presence situ significantly correlated (r=0.44, p<0.001), whilst was no significant association tumors or tumors.